Cells, tissues and organisms respond to physiological and environmental cues via signal transduction which has profound implications for diverse aspects of living organisms. The focus of our laboratory is to understand at the genetics and molecular levels, the complex series of inter-connected cascades in cell and how cells work to uncover the basis of human disease that ultimately leads to the development of diagnostic and therapeutic strategies to treatment. We also collaborate with expertise from different disciplines to solve a variety of distinct problems in our research areas including the regulation of signal transduction by protein phosphorylation through kinases and phosphatases, protein-protein and protein-gene interactions in signaling pathways and how mutations and polymorphisms affect these pathways and participate in the pathogenesis of human disease or medical conditions including thalassemia and hemophilia. We also actively apply high-throughput mass spectrometry-based metabolomics to study the signaling systems in microorganisms, particularly their secondary metabolites production which represent an important resource for drug discovery.